Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

Mice deficient in the pro-inflammatory cytokine IFNγ have improved glucose tolerance. Here, the authors show that this effect depends on the gut microbeAkkermansia muciniphila, whose abundance increases in the absence IFNγ, and which is known to have beneficial effects on host metabolism.

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Auteurs principaux: Renee L. Greer, Xiaoxi Dong, Ana Carolina F. Moraes, Ryszard A. Zielke, Gabriel R. Fernandes, Ekaterina Peremyslova, Stephany Vasquez-Perez, Alexi A. Schoenborn, Everton P. Gomes, Alexandre C. Pereira, Sandra R. G. Ferreira, Michael Yao, Ivan J. Fuss, Warren Strober, Aleksandra E. Sikora, Gregory A. Taylor, Ajay S. Gulati, Andrey Morgun, Natalia Shulzhenko
Format: article
Langue:EN
Publié: Nature Portfolio 2016
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/61494a965e404846a44ae00fc93376f4
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