Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A

Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A

Variants in the high confident autism spectrum disorder (ASD) gene ANK2 target both ubiquitously expressed 220 kDa ankyrin-B and neurospecific 440 kDa ankyrin-B (AnkB440) isoforms. Previous work showed that knock-in mice expressing an ASD-linked Ank2 variant yielding a truncated AnkB440 product exhi...

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Bibliographic Details
Main Authors: Blake A Creighton, Simone Afriyie, Deepa Ajit, Cristine R Casingal, Kayleigh M Voos, Joan Reger, April M Burch, Eric Dyne, Julia Bay, Jeffrey K Huang, ES Anton, Meng-Meng Fu, Damaris N Lorenzo
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
ankyrin
autism
growth cone
ANK2
axon branching
Sema 3a
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/617903977b8c47b6bcec06f59021d6f8
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https://doaj.org/article/617903977b8c47b6bcec06f59021d6f8

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