The plant-derived glucocorticoid receptor agonist Endiandrin A acts as co-stimulator of colonic epithelial sodium channels (ENaC) via SGK-1 and MAPKs.
In a search for secondary plant compounds that bind to the glucocorticoid receptor (GR), the cyclobutane lignan endiandrin A was discovered from the rainforest tree Endiandra anthropophagorum Domin. Our present study aims to characterize the effect of endiandrin A on GR-dependent induction of coloni...
Guardado en:
Autores principales: | Dana Kuntzsch, Theresa Bergann, Petra Dames, Anja Fromm, Michael Fromm, Rohan A Davis, Matthias F Melzig, Joerg D Schulzke |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2012
|
Materias: | |
Acceso en línea: | https://doaj.org/article/6195fe6796c545c2af4270a22eee55dc |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Aldosterone Modulates the Association between NCC and ENaC
por: Brandi M. Wynne, et al.
Publicado: (2017) -
Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis
por: Maria D. I. Manunta, et al.
Publicado: (2017) -
Drosophila nociceptors mediate larval aversion to dry surface environments utilizing both the painless TRP channel and the DEG/ENaC subunit, PPK1.
por: Wayne A Johnson, et al.
Publicado: (2012) -
Inhibition of Inflammation and Regulation of AQPs/ENaCs/Na+-K+-ATPase Mediated Alveolar Fluid Transport by Total Flavonoids Extracted From Nervilia fordii in Lipopolysaccharide-induced Acute Lung Injury
por: Shuomiao Yin, et al.
Publicado: (2021) -
A gene-based analysis of variants in the serum/glucocorticoid regulated kinase (SGK) genes with blood pressure responses to sodium intake: the GenSalt Study.
por: Changwei Li, et al.
Publicado: (2014)