An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline

An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline

HDAC6 is a tau deacetylase and acetylation of tau inhibits its function and promotes aggregation. Here the authors show that HDAC6 protects against tau accumulation in a mouse model of tauopathy.

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Auteurs principaux: Hanna Trzeciakiewicz, Deepa Ajit, Jui-Heng Tseng, Youjun Chen, Aditi Ajit, Zarin Tabassum, Rebecca Lobrovich, Claire Peterson, Natallia V. Riddick, Michelle S. Itano, Ashutosh Tripathy, Sheryl S. Moy, Virginia M. Y. Lee, John Q. Trojanowski, David J. Irwin, Todd J. Cohen
Format: article
Langue:EN
Publié: Nature Portfolio 2020
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/61ab6286279144ac8d59a59cc0805267
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Internet

https://doaj.org/article/61ab6286279144ac8d59a59cc0805267

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