Identification of potential chemical compounds enhancing generation of enucleated cells from immortalized human erythroid cell lines

In an imaging-based screen of >3,300 compounds compounds, Soboleva et al identify HDAC inhibitors as mediators of erythroid cell enucleation. They further show that the erythroid-specific cell membrane protein, SPTA1, is downregulated in HDAC inhibited cells and that restoration of SPTA1 expressi...

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Autores principales: Svetlana Soboleva, Ryo Kurita, Fredrik Ek, Hugo Åkerstrand, Rita Silvério-Alves, Roger Olsson, Yukio Nakamura, Kenichi Miharada
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/61f572de14eb48a18df29210fe97c443
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