Formal enantioconvergent substitution of alkyl halides via catalytic asymmetric photoredox radical coupling
Enantioselective substitution reactions of racemic alkyl halides are inherently limited by the specificity of their stereochemical course (SN1 or SN2). Here, the authors report a radical coupling strategy for the enantioselective aminoalkylation of α-bromoketones for modular, highly enantioselective...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/620596de496643598b0abf1cf4e483fc |
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| Sumario: | Enantioselective substitution reactions of racemic alkyl halides are inherently limited by the specificity of their stereochemical course (SN1 or SN2). Here, the authors report a radical coupling strategy for the enantioselective aminoalkylation of α-bromoketones for modular, highly enantioselective Csp3−Csp3 bond formation. |
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