Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes

Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes

Abstract Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) enable human cardiac cells to be studied in vitro, although they use glucose as their primary metabolic substrate and do not recapitulate the properties of adult cardiomyocytes. Here, we have explored the interplay betwe...

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Main Authors: Colleen A. Lopez, Heba Hussain A. A. Al-Siddiqi, Ujang Purnama, Sonia Iftekhar, Arne A. N. Bruyneel, Matthew Kerr, Rabia Nazir, Maria da Luz Sousa Fialho, Sophia Malandraki-Miller, Rita Alonaizan, Fatemeh Kermani, Lisa C. Heather, Jan Czernuszka, Carolyn A. Carr
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/620b82f11a04444ebfe740c6e09d998a
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