Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice

Toxoplasma gondii virulence in wild-derived mice is restricted by Immunity-Related GTPases (IRG). Here, the authors show specific binding of the IRG tandem protein Irgb2-b1 with the virulence effector ROP5, and provide insights into how different ROP5 isoforms and IRG alleles shape virulence among T...

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Autores principales: Mateo Murillo-León, Urs B. Müller, Ines Zimmermann, Shishir Singh, Pia Widdershooven, Cláudia Campos, Catalina Alvarez, Stephanie Könen-Waisman, Nahleen Lukes, Zsolt Ruzsics, Jonathan C. Howard, Martin Schwemmle, Tobias Steinfeldt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/6214204b6cb245a29596b1af94eefa25
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