Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice

Toxoplasma gondii virulence in wild-derived mice is restricted by Immunity-Related GTPases (IRG). Here, the authors show specific binding of the IRG tandem protein Irgb2-b1 with the virulence effector ROP5, and provide insights into how different ROP5 isoforms and IRG alleles shape virulence among T...

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Autores principales:	Mateo Murillo-León, Urs B. Müller, Ines Zimmermann, Shishir Singh, Pia Widdershooven, Cláudia Campos, Catalina Alvarez, Stephanie Könen-Waisman, Nahleen Lukes, Zsolt Ruzsics, Jonathan C. Howard, Martin Schwemmle, Tobias Steinfeldt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6214204b6cb245a29596b1af94eefa25
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spelling	oai:doaj.org-article:6214204b6cb245a29596b1af94eefa252021-12-02T17:01:40ZMolecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice10.1038/s41467-019-09200-22041-1723https://doaj.org/article/6214204b6cb245a29596b1af94eefa252019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09200-2https://doaj.org/toc/2041-1723Toxoplasma gondii virulence in wild-derived mice is restricted by Immunity-Related GTPases (IRG). Here, the authors show specific binding of the IRG tandem protein Irgb2-b1 with the virulence effector ROP5, and provide insights into how different ROP5 isoforms and IRG alleles shape virulence among T. gondii strains.Mateo Murillo-LeónUrs B. MüllerInes ZimmermannShishir SinghPia WiddershoovenCláudia CamposCatalina AlvarezStephanie Könen-WaismanNahleen LukesZsolt RuzsicsJonathan C. HowardMartin SchwemmleTobias SteinfeldtNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mateo Murillo-León Urs B. Müller Ines Zimmermann Shishir Singh Pia Widdershooven Cláudia Campos Catalina Alvarez Stephanie Könen-Waisman Nahleen Lukes Zsolt Ruzsics Jonathan C. Howard Martin Schwemmle Tobias Steinfeldt Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice
description	Toxoplasma gondii virulence in wild-derived mice is restricted by Immunity-Related GTPases (IRG). Here, the authors show specific binding of the IRG tandem protein Irgb2-b1 with the virulence effector ROP5, and provide insights into how different ROP5 isoforms and IRG alleles shape virulence among T. gondii strains.
format	article
author	Mateo Murillo-León Urs B. Müller Ines Zimmermann Shishir Singh Pia Widdershooven Cláudia Campos Catalina Alvarez Stephanie Könen-Waisman Nahleen Lukes Zsolt Ruzsics Jonathan C. Howard Martin Schwemmle Tobias Steinfeldt
author_facet	Mateo Murillo-León Urs B. Müller Ines Zimmermann Shishir Singh Pia Widdershooven Cláudia Campos Catalina Alvarez Stephanie Könen-Waisman Nahleen Lukes Zsolt Ruzsics Jonathan C. Howard Martin Schwemmle Tobias Steinfeldt
author_sort	Mateo Murillo-León
title	Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice
title_short	Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice
title_full	Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice
title_fullStr	Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice
title_full_unstemmed	Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice
title_sort	molecular mechanism for the control of virulent toxoplasma gondii infections in wild-derived mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6214204b6cb245a29596b1af94eefa25
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Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice

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