Distinctive Role of the Systemic Inflammatory Profile in Non-Small-Cell Lung Cancer Younger and Elderly Patients Treated with a PD-1 Immune Checkpoint Blockade: A Real-World Retrospective Multi-Institutional Analysis

Distinctive Role of the Systemic Inflammatory Profile in Non-Small-Cell Lung Cancer Younger and Elderly Patients Treated with a PD-1 Immune Checkpoint Blockade: A Real-World Retrospective Multi-Institutional Analysis

An immune checkpoint blockade with mAbs to PD-1 and PD-L1 is an expanding therapeutic option for mNSCLC patients. This treatment strategy is based on the use of mAbs able to restore the anti-tumor activity of intratumoral T cells inhibited by PD-1 binding to PD-L1/2 on tumor and inflammatory cells....

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Main Authors: Valerio Nardone, Rocco Giannicola, Diana Giannarelli, Rita Emilena Saladino, Domenico Azzarello, Caterina Romeo, Giovanna Bianco, Maria Rosaria Rizzo, Irene Di Meo, Antonio Nesci, Pierpaolo Pastina, Antonia Consuelo Falzea, Daniele Caracciolo, Alfonso Reginelli, Michele Caraglia, Amalia Luce, Luciano Mutti, Antonio Giordano, Salvatore Cappabianca, Luigi Pirtoli, Vito Barbieri, Pierfrancesco Tassone, Pierosandro Tagliaferri, Pierpaolo Correale
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
immune checkpoint blockade
metastatic non-small-cell lung cancer
real-world evidence study
age
inflammatory markers
immunotherapy
Science
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Online Access:https://doaj.org/article/62314baa55cc425bb501c2b7b1efcaef
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https://doaj.org/article/62314baa55cc425bb501c2b7b1efcaef

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