Optimal control nodes in disease-perturbed networks as targets for combination therapy

Synergistic interactions may arise between regulators in complex molecular networks. Here, the authors develop OptiCon, a computational method for de novo identification of synergistic key regulators and investigate their potential roles as candidate targets for combination therapy.

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Detalles Bibliográficos
Autores principales: Yuxuan Hu, Chia-hui Chen, Yang-yang Ding, Xiao Wen, Bingbo Wang, Lin Gao, Kai Tan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/624d36751a5444ffbd9a2a54c5ce94db
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