Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy

The ULK complex plays a well-known role in initiating autophagy, to recycle cellular components in response to nutritional stress. Here, the authors demonstrate a late role for ULK in auotophagosome–lysosome fusion and provide a direct link between macroautophagy and chaperone mediated autophagy.

Guardado en:

Detalles Bibliográficos
Autores principales:	Chenyao Wang, Huafei Wang, Deyi Zhang, Wenwen Luo, Ruilong Liu, Daqian Xu, Lei Diao, Lujian Liao, Zhixue Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62852709b9784c59a2fbefdf94a827c2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:62852709b9784c59a2fbefdf94a827c2
record_format	dspace
spelling	oai:doaj.org-article:62852709b9784c59a2fbefdf94a827c22021-12-02T17:32:02ZPhosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy10.1038/s41467-018-05449-12041-1723https://doaj.org/article/62852709b9784c59a2fbefdf94a827c22018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05449-1https://doaj.org/toc/2041-1723The ULK complex plays a well-known role in initiating autophagy, to recycle cellular components in response to nutritional stress. Here, the authors demonstrate a late role for ULK in auotophagosome–lysosome fusion and provide a direct link between macroautophagy and chaperone mediated autophagy.Chenyao WangHuafei WangDeyi ZhangWenwen LuoRuilong LiuDaqian XuLei DiaoLujian LiaoZhixue LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chenyao Wang Huafei Wang Deyi Zhang Wenwen Luo Ruilong Liu Daqian Xu Lei Diao Lujian Liao Zhixue Liu Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
description	The ULK complex plays a well-known role in initiating autophagy, to recycle cellular components in response to nutritional stress. Here, the authors demonstrate a late role for ULK in auotophagosome–lysosome fusion and provide a direct link between macroautophagy and chaperone mediated autophagy.
format	article
author	Chenyao Wang Huafei Wang Deyi Zhang Wenwen Luo Ruilong Liu Daqian Xu Lei Diao Lujian Liao Zhixue Liu
author_facet	Chenyao Wang Huafei Wang Deyi Zhang Wenwen Luo Ruilong Liu Daqian Xu Lei Diao Lujian Liao Zhixue Liu
author_sort	Chenyao Wang
title	Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
title_short	Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
title_full	Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
title_fullStr	Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
title_full_unstemmed	Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
title_sort	phosphorylation of ulk1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/62852709b9784c59a2fbefdf94a827c2
work_keys_str_mv	AT chenyaowang phosphorylationofulk1affectsautophagosomefusionandlinkschaperonemediatedautophagytomacroautophagy AT huafeiwang phosphorylationofulk1affectsautophagosomefusionandlinkschaperonemediatedautophagytomacroautophagy AT deyizhang phosphorylationofulk1affectsautophagosomefusionandlinkschaperonemediatedautophagytomacroautophagy AT wenwenluo phosphorylationofulk1affectsautophagosomefusionandlinkschaperonemediatedautophagytomacroautophagy AT ruilongliu phosphorylationofulk1affectsautophagosomefusionandlinkschaperonemediatedautophagytomacroautophagy AT daqianxu phosphorylationofulk1affectsautophagosomefusionandlinkschaperonemediatedautophagytomacroautophagy AT leidiao phosphorylationofulk1affectsautophagosomefusionandlinkschaperonemediatedautophagytomacroautophagy AT lujianliao phosphorylationofulk1affectsautophagosomefusionandlinkschaperonemediatedautophagytomacroautophagy AT zhixueliu phosphorylationofulk1affectsautophagosomefusionandlinkschaperonemediatedautophagytomacroautophagy
_version_	1718380432037249024

Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy

Ejemplares similares