The Effects of Different Hormones on Supraventricular and Ventricular Premature Contractions in Healthy Premenopausal Women
<i>Background and Objectives</i>: The effects of gender differences on cardiac parameters have been well-established. In this study, we aimed to evaluate the possible associations of plasma levels of different sex hormones with premature atrial or ventricular contractions in premenopausa...
Guardado en:
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
MDPI AG
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/62b17628d0bd480b8011dc777ca99c1b |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:62b17628d0bd480b8011dc777ca99c1b |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:62b17628d0bd480b8011dc777ca99c1b2021-11-25T18:18:08ZThe Effects of Different Hormones on Supraventricular and Ventricular Premature Contractions in Healthy Premenopausal Women10.3390/medicina571111541648-91441010-660Xhttps://doaj.org/article/62b17628d0bd480b8011dc777ca99c1b2021-10-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1154https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and Objectives</i>: The effects of gender differences on cardiac parameters have been well-established. In this study, we aimed to evaluate the possible associations of plasma levels of different sex hormones with premature atrial or ventricular contractions in premenopausal women. <i>Materials and Methods</i>: We conducted a prospective study which included women in late reproductive age who presented with palpitations during an eight-month period. A 12-lead electrocardiography, a transthoracic echocardiogram, blood samples, and 24-hour rhythm Holter were conducted on the third day of the menstrual cycle. <i>Results</i> Overall, 93 healthy premenopausal women with a median age of 42 years were enrolled. QTc interval was within normal limits in all patients. The 24 h range of premature atrial contractions (PACs) and premature ventricular contractions (PVCs) was 0–6450 and was 0–21,230, respectively. The median number of PVCs was 540 and the median number of PACs was 212, respectively. In total, 51 patients (54.8%) had a frequency of PVCs > 500/24 h and 37 patients (39.8%) had a frequency of PACs > 500/24 h, respectively. No statistically significant association was shown between any hormone and the frequency of PACs. Regarding PVCs, patients with a PVCs frequency > 500/24 h had higher estradiol levels compared to patients with PVCs less than 500/24 h (median 60 pg/mL versus 42 pg/mL, <i>p</i> = 0.02, OR: 1.01). No association was found between PVCs and other hormones. <i>Conclusions</i>: In premenopausal healthy women, higher estradiol levels are independently associated with increased PVCs. This suggests that estradiol in late reproductive stages may exert proarrhythmic effects.Elias TsougosEmmanouil KorakasVasileios KolovosGeorgia-Angeliki KoliouGeorgios PapageorgiouAikaterini KountouriKonstantinos BalampanisLoukia PlioutaSavvas LoizosNikolaos KaramichalakisElias GatosIgnatios IkonomidisParaskevi KazakouAthanasios RaptisVaia LambadiariMDPI AGarticleestradiolprogesteronepremature ventricular contractionsmenstrual cyclearrhythmiasMedicine (General)R5-920ENMedicina, Vol 57, Iss 1154, p 1154 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
estradiol progesterone premature ventricular contractions menstrual cycle arrhythmias Medicine (General) R5-920 |
spellingShingle |
estradiol progesterone premature ventricular contractions menstrual cycle arrhythmias Medicine (General) R5-920 Elias Tsougos Emmanouil Korakas Vasileios Kolovos Georgia-Angeliki Koliou Georgios Papageorgiou Aikaterini Kountouri Konstantinos Balampanis Loukia Pliouta Savvas Loizos Nikolaos Karamichalakis Elias Gatos Ignatios Ikonomidis Paraskevi Kazakou Athanasios Raptis Vaia Lambadiari The Effects of Different Hormones on Supraventricular and Ventricular Premature Contractions in Healthy Premenopausal Women |
description |
<i>Background and Objectives</i>: The effects of gender differences on cardiac parameters have been well-established. In this study, we aimed to evaluate the possible associations of plasma levels of different sex hormones with premature atrial or ventricular contractions in premenopausal women. <i>Materials and Methods</i>: We conducted a prospective study which included women in late reproductive age who presented with palpitations during an eight-month period. A 12-lead electrocardiography, a transthoracic echocardiogram, blood samples, and 24-hour rhythm Holter were conducted on the third day of the menstrual cycle. <i>Results</i> Overall, 93 healthy premenopausal women with a median age of 42 years were enrolled. QTc interval was within normal limits in all patients. The 24 h range of premature atrial contractions (PACs) and premature ventricular contractions (PVCs) was 0–6450 and was 0–21,230, respectively. The median number of PVCs was 540 and the median number of PACs was 212, respectively. In total, 51 patients (54.8%) had a frequency of PVCs > 500/24 h and 37 patients (39.8%) had a frequency of PACs > 500/24 h, respectively. No statistically significant association was shown between any hormone and the frequency of PACs. Regarding PVCs, patients with a PVCs frequency > 500/24 h had higher estradiol levels compared to patients with PVCs less than 500/24 h (median 60 pg/mL versus 42 pg/mL, <i>p</i> = 0.02, OR: 1.01). No association was found between PVCs and other hormones. <i>Conclusions</i>: In premenopausal healthy women, higher estradiol levels are independently associated with increased PVCs. This suggests that estradiol in late reproductive stages may exert proarrhythmic effects. |
format |
article |
author |
Elias Tsougos Emmanouil Korakas Vasileios Kolovos Georgia-Angeliki Koliou Georgios Papageorgiou Aikaterini Kountouri Konstantinos Balampanis Loukia Pliouta Savvas Loizos Nikolaos Karamichalakis Elias Gatos Ignatios Ikonomidis Paraskevi Kazakou Athanasios Raptis Vaia Lambadiari |
author_facet |
Elias Tsougos Emmanouil Korakas Vasileios Kolovos Georgia-Angeliki Koliou Georgios Papageorgiou Aikaterini Kountouri Konstantinos Balampanis Loukia Pliouta Savvas Loizos Nikolaos Karamichalakis Elias Gatos Ignatios Ikonomidis Paraskevi Kazakou Athanasios Raptis Vaia Lambadiari |
author_sort |
Elias Tsougos |
title |
The Effects of Different Hormones on Supraventricular and Ventricular Premature Contractions in Healthy Premenopausal Women |
title_short |
The Effects of Different Hormones on Supraventricular and Ventricular Premature Contractions in Healthy Premenopausal Women |
title_full |
The Effects of Different Hormones on Supraventricular and Ventricular Premature Contractions in Healthy Premenopausal Women |
title_fullStr |
The Effects of Different Hormones on Supraventricular and Ventricular Premature Contractions in Healthy Premenopausal Women |
title_full_unstemmed |
The Effects of Different Hormones on Supraventricular and Ventricular Premature Contractions in Healthy Premenopausal Women |
title_sort |
effects of different hormones on supraventricular and ventricular premature contractions in healthy premenopausal women |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/62b17628d0bd480b8011dc777ca99c1b |
work_keys_str_mv |
AT eliastsougos theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT emmanouilkorakas theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT vasileioskolovos theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT georgiaangelikikoliou theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT georgiospapageorgiou theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT aikaterinikountouri theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT konstantinosbalampanis theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT loukiapliouta theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT savvasloizos theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT nikolaoskaramichalakis theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT eliasgatos theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT ignatiosikonomidis theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT paraskevikazakou theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT athanasiosraptis theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT vaialambadiari theeffectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT eliastsougos effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT emmanouilkorakas effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT vasileioskolovos effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT georgiaangelikikoliou effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT georgiospapageorgiou effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT aikaterinikountouri effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT konstantinosbalampanis effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT loukiapliouta effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT savvasloizos effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT nikolaoskaramichalakis effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT eliasgatos effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT ignatiosikonomidis effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT paraskevikazakou effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT athanasiosraptis effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen AT vaialambadiari effectsofdifferenthormonesonsupraventricularandventricularprematurecontractionsinhealthypremenopausalwomen |
_version_ |
1718411384533811200 |