Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP

The inner centromere protein (INCENP) activates Aurora kinase B (AURKB) and Aurora kinase C. Here the authors provide insights into the activation mechanism of AURKB/C by determining the crystal structure of fully active phosphorylated human AURKC bound to the phosphorylated C-terminal IN-box sectio...

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Autores principales:	Kamal R. Abdul Azeez, Sneha Chatterjee, Channing Yu, Todd R. Golub, Frank Sobott, Jonathan M. Elkins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62e11b721bf345adba1dccc00528f587
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spelling	oai:doaj.org-article:62e11b721bf345adba1dccc00528f5872021-12-02T17:01:37ZStructural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP10.1038/s41467-019-11085-02041-1723https://doaj.org/article/62e11b721bf345adba1dccc00528f5872019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11085-0https://doaj.org/toc/2041-1723The inner centromere protein (INCENP) activates Aurora kinase B (AURKB) and Aurora kinase C. Here the authors provide insights into the activation mechanism of AURKB/C by determining the crystal structure of fully active phosphorylated human AURKC bound to the phosphorylated C-terminal IN-box section of human INCENP.Kamal R. Abdul AzeezSneha ChatterjeeChanning YuTodd R. GolubFrank SobottJonathan M. ElkinsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kamal R. Abdul Azeez Sneha Chatterjee Channing Yu Todd R. Golub Frank Sobott Jonathan M. Elkins Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP
description	The inner centromere protein (INCENP) activates Aurora kinase B (AURKB) and Aurora kinase C. Here the authors provide insights into the activation mechanism of AURKB/C by determining the crystal structure of fully active phosphorylated human AURKC bound to the phosphorylated C-terminal IN-box section of human INCENP.
format	article
author	Kamal R. Abdul Azeez Sneha Chatterjee Channing Yu Todd R. Golub Frank Sobott Jonathan M. Elkins
author_facet	Kamal R. Abdul Azeez Sneha Chatterjee Channing Yu Todd R. Golub Frank Sobott Jonathan M. Elkins
author_sort	Kamal R. Abdul Azeez
title	Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP
title_short	Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP
title_full	Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP
title_fullStr	Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP
title_full_unstemmed	Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP
title_sort	structural mechanism of synergistic activation of aurora kinase b/c by phosphorylated incenp
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/62e11b721bf345adba1dccc00528f587
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Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP

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