Plasmid-mediated metronidazole resistance in Clostridioides difficile

Cases of C. difficile (CD) resistant to metronidazole have been reported but the mechanism remains enigmatic. Here the authors identify a plasmid, which correlates with metronidazole resistance status in a large international collection of CD isolates, and demonstrate that the plasmid can confer met...

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Main Authors: Ilse M. Boekhoud, Bastian V. H. Hornung, Eloisa Sevilla, Céline Harmanus, Ingrid M. J. G. Bos-Sanders, Elisabeth M. Terveer, Rosa Bolea, Jeroen Corver, Ed J. Kuijper, Wiep Klaas Smits
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/62feb273069b45dbbfbfc70da53d3cb5
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