Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study

Background: Worldwide, coffee is one of the most popular beverages consumed. Several studies have suggested a protective role of coffee, including reduced risk of Alzheimer’s disease (AD). However, there is limited longitudinal data from cohorts of older adults reporting associations of coffee intak...

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Autores principales:	Samantha L. Gardener, Stephanie R. Rainey-Smith, Victor L. Villemagne, Jurgen Fripp, Vincent Doré, Pierrick Bourgeat, Kevin Taddei, Christopher Fowler, Colin L. Masters, Paul Maruff, Christopher C. Rowe, David Ames, Ralph N. Martins, the AIBL Investigators
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	coffee Alzheimer’s disease AIBL Australian Imaging Biomarkers and Lifestyle flagship study of ageing caffeine cognitive decline Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/630a4aaa35384b7b8e7be42ffd2064af
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spelling	oai:doaj.org-article:630a4aaa35384b7b8e7be42ffd2064af2021-11-19T16:26:56ZHigher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study1663-436510.3389/fnagi.2021.744872https://doaj.org/article/630a4aaa35384b7b8e7be42ffd2064af2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.744872/fullhttps://doaj.org/toc/1663-4365Background: Worldwide, coffee is one of the most popular beverages consumed. Several studies have suggested a protective role of coffee, including reduced risk of Alzheimer’s disease (AD). However, there is limited longitudinal data from cohorts of older adults reporting associations of coffee intake with cognitive decline, in distinct domains, and investigating the neuropathological mechanisms underpinning any such associations.Methods: The aim of the current study was to investigate the relationship between self-reported habitual coffee intake, and cognitive decline assessed using a comprehensive neuropsychological battery in 227 cognitively normal older adults from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) study, over 126 months. In a subset of individuals, we also investigated the relationship between habitual coffee intake and cerebral Aβ-amyloid accumulation (n = 60) and brain volumes (n = 51) over 126 months.Results: Higher baseline coffee consumption was associated with slower cognitive decline in executive function, attention, and the AIBL Preclinical AD Cognitive Composite (PACC; shown reliably to measure the first signs of cognitive decline in at-risk cognitively normal populations), and lower likelihood of transitioning to mild cognitive impairment or AD status, over 126 months. Higher baseline coffee consumption was also associated with slower Aβ-amyloid accumulation over 126 months, and lower risk of progressing to “moderate,” “high,” or “very high” Aβ-amyloid burden status over the same time-period. There were no associations between coffee intake and atrophy in total gray matter, white matter, or hippocampal volume.Discussion: Our results further support the hypothesis that coffee intake may be a protective factor against AD, with increased coffee consumption potentially reducing cognitive decline by slowing cerebral Aβ-amyloid accumulation, and thus attenuating the associated neurotoxicity from Aβ-amyloid-mediated oxidative stress and inflammatory processes. Further investigation is required to evaluate whether coffee intake could be incorporated as a modifiable lifestyle factor aimed at delaying AD onset.Samantha L. GardenerSamantha L. GardenerStephanie R. Rainey-SmithStephanie R. Rainey-SmithStephanie R. Rainey-SmithStephanie R. Rainey-SmithVictor L. VillemagneJurgen FrippVincent DoréVincent DoréPierrick BourgeatKevin TaddeiKevin TaddeiChristopher FowlerColin L. MastersPaul MaruffPaul MaruffChristopher C. RoweChristopher C. RoweDavid AmesDavid AmesRalph N. MartinsRalph N. MartinsRalph N. Martinsthe AIBL InvestigatorsFrontiers Media S.A.articlecoffeeAlzheimer’s diseaseAIBLAustralian Imaging Biomarkers and Lifestyle flagship study of ageingcaffeinecognitive declineNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coffee Alzheimer’s disease AIBL Australian Imaging Biomarkers and Lifestyle flagship study of ageing caffeine cognitive decline Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	coffee Alzheimer’s disease AIBL Australian Imaging Biomarkers and Lifestyle flagship study of ageing caffeine cognitive decline Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Samantha L. Gardener Samantha L. Gardener Stephanie R. Rainey-Smith Stephanie R. Rainey-Smith Stephanie R. Rainey-Smith Stephanie R. Rainey-Smith Victor L. Villemagne Jurgen Fripp Vincent Doré Vincent Doré Pierrick Bourgeat Kevin Taddei Kevin Taddei Christopher Fowler Colin L. Masters Paul Maruff Paul Maruff Christopher C. Rowe Christopher C. Rowe David Ames David Ames Ralph N. Martins Ralph N. Martins Ralph N. Martins the AIBL Investigators Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
description	Background: Worldwide, coffee is one of the most popular beverages consumed. Several studies have suggested a protective role of coffee, including reduced risk of Alzheimer’s disease (AD). However, there is limited longitudinal data from cohorts of older adults reporting associations of coffee intake with cognitive decline, in distinct domains, and investigating the neuropathological mechanisms underpinning any such associations.Methods: The aim of the current study was to investigate the relationship between self-reported habitual coffee intake, and cognitive decline assessed using a comprehensive neuropsychological battery in 227 cognitively normal older adults from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) study, over 126 months. In a subset of individuals, we also investigated the relationship between habitual coffee intake and cerebral Aβ-amyloid accumulation (n = 60) and brain volumes (n = 51) over 126 months.Results: Higher baseline coffee consumption was associated with slower cognitive decline in executive function, attention, and the AIBL Preclinical AD Cognitive Composite (PACC; shown reliably to measure the first signs of cognitive decline in at-risk cognitively normal populations), and lower likelihood of transitioning to mild cognitive impairment or AD status, over 126 months. Higher baseline coffee consumption was also associated with slower Aβ-amyloid accumulation over 126 months, and lower risk of progressing to “moderate,” “high,” or “very high” Aβ-amyloid burden status over the same time-period. There were no associations between coffee intake and atrophy in total gray matter, white matter, or hippocampal volume.Discussion: Our results further support the hypothesis that coffee intake may be a protective factor against AD, with increased coffee consumption potentially reducing cognitive decline by slowing cerebral Aβ-amyloid accumulation, and thus attenuating the associated neurotoxicity from Aβ-amyloid-mediated oxidative stress and inflammatory processes. Further investigation is required to evaluate whether coffee intake could be incorporated as a modifiable lifestyle factor aimed at delaying AD onset.
format	article
author	Samantha L. Gardener Samantha L. Gardener Stephanie R. Rainey-Smith Stephanie R. Rainey-Smith Stephanie R. Rainey-Smith Stephanie R. Rainey-Smith Victor L. Villemagne Jurgen Fripp Vincent Doré Vincent Doré Pierrick Bourgeat Kevin Taddei Kevin Taddei Christopher Fowler Colin L. Masters Paul Maruff Paul Maruff Christopher C. Rowe Christopher C. Rowe David Ames David Ames Ralph N. Martins Ralph N. Martins Ralph N. Martins the AIBL Investigators
author_facet	Samantha L. Gardener Samantha L. Gardener Stephanie R. Rainey-Smith Stephanie R. Rainey-Smith Stephanie R. Rainey-Smith Stephanie R. Rainey-Smith Victor L. Villemagne Jurgen Fripp Vincent Doré Vincent Doré Pierrick Bourgeat Kevin Taddei Kevin Taddei Christopher Fowler Colin L. Masters Paul Maruff Paul Maruff Christopher C. Rowe Christopher C. Rowe David Ames David Ames Ralph N. Martins Ralph N. Martins Ralph N. Martins the AIBL Investigators
author_sort	Samantha L. Gardener
title	Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
title_short	Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
title_full	Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
title_fullStr	Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
title_full_unstemmed	Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
title_sort	higher coffee consumption is associated with slower cognitive decline and less cerebral aβ-amyloid accumulation over 126 months: data from the australian imaging, biomarkers, and lifestyle study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/630a4aaa35384b7b8e7be42ffd2064af
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Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study

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