Sodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of NLRP3 and IL-1β

Sodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of NLRP3 and IL-1β

Sodium butyrate (NaB) is a by-product of dietary fiber that has an anti-tumor effect on colorectal cancer (CRC). The aim of this study was to explore the effect of NaB on tumor and colitis using a colitis-associated colorectal cancer (CAC) model. CAC model was induced in mice by administration of az...

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Autores principales: Huahuan Liu, Zhongbo Bian, Qiuyu Zhang, Zhipeng Xiao, Yu Cao, Xiaodie Sun, Yong Qin, Lianzhi Mao, Xinwei Chu, Wenzhen Liao, Longying Zha, Suxia Sun
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
Sodium butyrate
AOM/DSS
Gut microbiota
NLRP3
Colorectal cancer
Nutrition. Foods and food supply
TX341-641
Acceso en línea:https://doaj.org/article/631440c24edc4d518822b0b817b1dd07
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spelling oai:doaj.org-article:631440c24edc4d518822b0b817b1dd072021-11-24T04:27:37ZSodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of NLRP3 and IL-1β1756-464610.1016/j.jff.2021.104862https://doaj.org/article/631440c24edc4d518822b0b817b1dd072021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621005119https://doaj.org/toc/1756-4646Sodium butyrate (NaB) is a by-product of dietary fiber that has an anti-tumor effect on colorectal cancer (CRC). The aim of this study was to explore the effect of NaB on tumor and colitis using a colitis-associated colorectal cancer (CAC) model. CAC model was induced in mice by administration of azoxymethane (AOM) and dextran sulfate sodium salt (DSS). 0.1 M NaB in drinking water, or intraperitoneal injection of NaB (1 g/kg body weight) was given during the study period. NLRP3 inflammasome-related molecules were detected. The composition and taxonomy of colorectal microbiota were analyzed. NaB increased spleen index decreased by AOM/DSS. NaB attenuated tumors by reducing tumor load and tumor size in AOM/DSS-induced mice. NaB protected mice from CAC by improving colitis and inhibiting expression of NLRP3 and IL-1β. NaB regulated gut microbiota dysbiosis induced by AOM/DSS. In conclusion, NaB inhibited CAC by ameliorating the gut microbiota dysbiosis and inhibiting colitis.Huahuan LiuZhongbo BianQiuyu ZhangZhipeng XiaoYu CaoXiaodie SunYong QinLianzhi MaoXinwei ChuWenzhen LiaoLongying ZhaSuxia SunElsevierarticleSodium butyrateAOM/DSSGut microbiotaNLRP3Colorectal cancerNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104862- (2021)
institution DOAJ
collection DOAJ
language EN
topic Sodium butyrate
AOM/DSS
Gut microbiota
NLRP3
Colorectal cancer
Nutrition. Foods and food supply
TX341-641
spellingShingle Sodium butyrate
AOM/DSS
Gut microbiota
NLRP3
Colorectal cancer
Nutrition. Foods and food supply
TX341-641
Huahuan Liu
Zhongbo Bian
Qiuyu Zhang
Zhipeng Xiao
Yu Cao
Xiaodie Sun
Yong Qin
Lianzhi Mao
Xinwei Chu
Wenzhen Liao
Longying Zha
Suxia Sun
Sodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of NLRP3 and IL-1β
description Sodium butyrate (NaB) is a by-product of dietary fiber that has an anti-tumor effect on colorectal cancer (CRC). The aim of this study was to explore the effect of NaB on tumor and colitis using a colitis-associated colorectal cancer (CAC) model. CAC model was induced in mice by administration of azoxymethane (AOM) and dextran sulfate sodium salt (DSS). 0.1 M NaB in drinking water, or intraperitoneal injection of NaB (1 g/kg body weight) was given during the study period. NLRP3 inflammasome-related molecules were detected. The composition and taxonomy of colorectal microbiota were analyzed. NaB increased spleen index decreased by AOM/DSS. NaB attenuated tumors by reducing tumor load and tumor size in AOM/DSS-induced mice. NaB protected mice from CAC by improving colitis and inhibiting expression of NLRP3 and IL-1β. NaB regulated gut microbiota dysbiosis induced by AOM/DSS. In conclusion, NaB inhibited CAC by ameliorating the gut microbiota dysbiosis and inhibiting colitis.
format article
author Huahuan Liu
Zhongbo Bian
Qiuyu Zhang
Zhipeng Xiao
Yu Cao
Xiaodie Sun
Yong Qin
Lianzhi Mao
Xinwei Chu
Wenzhen Liao
Longying Zha
Suxia Sun
author_facet Huahuan Liu
Zhongbo Bian
Qiuyu Zhang
Zhipeng Xiao
Yu Cao
Xiaodie Sun
Yong Qin
Lianzhi Mao
Xinwei Chu
Wenzhen Liao
Longying Zha
Suxia Sun
author_sort Huahuan Liu
title Sodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of NLRP3 and IL-1β
title_short Sodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of NLRP3 and IL-1β
title_full Sodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of NLRP3 and IL-1β
title_fullStr Sodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of NLRP3 and IL-1β
title_full_unstemmed Sodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of NLRP3 and IL-1β
title_sort sodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of nlrp3 and il-1β
publisher Elsevier
publishDate 2021
url https://doaj.org/article/631440c24edc4d518822b0b817b1dd07
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