Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections.

Invasive fungal infections by Candida albicans (Ca) are a frequent cause of lethal sepsis in intensive care unit patients. While a contribution of type I interferons (IFNs-I) in fungal sepsis remains unknown, these immunostimulatory cytokines mediate the lethal effects of endotoxemia and bacterial s...

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Autores principales: Olivia Majer, Christelle Bourgeois, Florian Zwolanek, Caroline Lassnig, Dontscho Kerjaschki, Matthias Mack, Mathias Müller, Karl Kuchler
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/6324bc6ddc8248498c30959bdbb51009
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