T cell receptor recognition of CD1b presenting a mycobacterial glycolipid

T cell receptor recognition of CD1b presenting a mycobacterial glycolipid

Germline-encoded mycolyl lipid-reactive (GEM) T cells recognize CD1b proteins presenting mycobacterial mycolates via their T-cell receptors (TCRs). Here, the authors present the structure of this interaction and provide a molecular basis for the co-recognition of CD1b and a mycobacterial glycolipid.

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Detalles Bibliográficos
Autores principales: Stephanie Gras, Ildiko Van Rhijn, Adam Shahine, Tan-Yun Cheng, Mugdha Bhati, Li Lynn Tan, Hanim Halim, Kathryn D. Tuttle, Laurent Gapin, Jérôme Le Nours, D. Branch Moody, Jamie Rossjohn
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/6334ebee5b454f54b0c32fa67fdc1261
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Descripción
Sumario:Germline-encoded mycolyl lipid-reactive (GEM) T cells recognize CD1b proteins presenting mycobacterial mycolates via their T-cell receptors (TCRs). Here, the authors present the structure of this interaction and provide a molecular basis for the co-recognition of CD1b and a mycobacterial glycolipid.

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