Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F<sub>420</sub>-0 in Mycobacteria

Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F<sub>420</sub>-0 in Mycobacteria

ABSTRACT F420 is a low-potential redox cofactor used by diverse bacteria and archaea. In mycobacteria, this cofactor has multiple roles, including adaptation to redox stress, cell wall biosynthesis, and activation of the clinical antitubercular prodrugs pretomanid and delamanid. A recent biochemical...

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Autores principales: Rhys Grinter, Blair Ney, Rajini Brammananth, Christopher K. Barlow, Paul R. F. Cordero, David L. Gillett, Thierry Izoré, Max J. Cryle, Liam K. Harold, Gregory M. Cook, George Taiaroa, Deborah A. Williamson, Andrew C. Warden, John G. Oakeshott, Matthew C. Taylor, Paul K. Crellin, Colin J. Jackson, Ralf B. Schittenhelm, Ross L. Coppel, Chris Greening
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
cofactor biosynthesis
deazaflavin
F420
Mycobacterium
Mycobacterium smegmatis
structural biology
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/63558d0234fb43f688726db29ee00c9a
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