Essentiality of Succinate Dehydrogenase in <named-content content-type="genus-species">Mycobacterium smegmatis</named-content> and Its Role in the Generation of the Membrane Potent...

par Ildiko Pecsi, Kiel Hards, Nandula Ekanayaka, Michael Berney, Travis Hartman, William R. Jacobs, Gregory M. Cook
Publié 2014

Genomewide Profiling of the <named-content content-type="genus-species">Enterococcus faecalis</named-content> Transcriptional Response to Teixobactin Reveals CroRS as an Essential...

par Rachel L. Darnell, Melanie K. Knottenbelt, Francesca O. Todd Rose, Ian R. Monk, Timothy P. Stinear, Gregory M. Cook
Publié 2019

Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection

par Erik J. Hasenoehrl, Dannah Rae Sajorda, Linda Berney-Meyer, Samantha Johnson, JoAnn M. Tufariello, Tobias Fuhrer, Gregory M. Cook, William R. Jacobs, Michael Berney
Publié 2019

The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB

par Schara Safarian, Helen K. Opel-Reading, Di Wu, Ahmad R. Mehdipour, Kiel Hards, Liam K. Harold, Melanie Radloff, Ian Stewart, Sonja Welsch, Gerhard Hummer, Gregory M. Cook, Kurt L. Krause, Hartmut Michel
Publié 2021

Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2

par Nichaela Harbison-Price, Scott A. Ferguson, Adam Heikal, George Taiaroa, Kiel Hards, Yoshio Nakatani, David Rennison, Margaret A. Brimble, Ibrahim M. El-Deeb, Lisa Bohlmann, Christopher A. McDevitt, Mark von Itzstein, Mark J. Walker, Gregory M. Cook
Publié 2020

Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F₄₂₀-0 in Mycobacteria

par Rhys Grinter, Blair Ney, Rajini Brammananth, Christopher K. Barlow, Paul R. F. Cordero, David L. Gillett, Thierry Izoré, Max J. Cryle, Liam K. Harold, Gregory M. Cook, George Taiaroa, Deborah A. Williamson, Andrew C. Warden, John G. Oakeshott, Matthew C. Taylor, Paul K. Crellin, Colin J. Jackson, Ralf B. Schittenhelm, Ross L. Coppel, Chris Greening
Publié 2020

Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance

par Lisa Bohlmann, David M. P. De Oliveira, Ibrahim M. El-Deeb, Erin B. Brazel, Nichaela Harbison-Price, Cheryl-lynn Y. Ong, Tania Rivera-Hernandez, Scott A. Ferguson, Amanda J. Cork, Minh-Duy Phan, Amelia T. Soderholm, Mark R. Davies, Graeme R. Nimmo, Gordon Dougan, Mark A. Schembri, Gregory M. Cook, Alastair G. McEwan, Mark von Itzstein, Christopher A. McDevitt, Mark J. Walker
Publié 2018