Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application

por Christopher A. Kerantzas, William R. Jacobs
Publicado 2017

Postprimary Tuberculosis and Macrophage Necrosis: Is There a Big ConNECtion?

por Ka-Wing Wong, William R. Jacobs
Publicado 2016

A <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Cytochrome <italic toggle="yes">bd</italic> Oxidase Mutant Is Hypersensitive to Bedaquiline

por Michael Berney, Travis E. Hartman, William R. Jacobs
Publicado 2014

Sterilization by Adaptive Immunity of a Conditionally Persistent Mutant of Mycobacterium tuberculosis

por Catherine Vilchèze, Steven A. Porcelli, John Chan, William R. Jacobs
Publicado 2021

An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis.

por Anthony D Baughn, Scott J Garforth, Catherine Vilchèze, William R Jacobs
Publicado 2009

Essentiality of Succinate Dehydrogenase in <named-content content-type="genus-species">Mycobacterium smegmatis</named-content> and Its Role in the Generation of the Membrane Potent...

por Ildiko Pecsi, Kiel Hards, Nandula Ekanayaka, Michael Berney, Travis Hartman, William R. Jacobs, Gregory M. Cook
Publicado 2014

Acetic Acid, the Active Component of Vinegar, Is an Effective Tuberculocidal Disinfectant

por Claudia Cortesia, Catherine Vilchèze, Audrey Bernut, Whendy Contreras, Keyla Gómez, Jacobus de Waard, William R. Jacobs, Laurent Kremer, Howard Takiff
Publicado 2014

Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> through Nutrien...

por Catherine Vilchèze, Jacqueline Copeland, Tracy L. Keiser, Torin Weisbrod, Jacqueline Washington, Paras Jain, Adel Malek, Brian Weinrick, William R. Jacobs
Publicado 2018

Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>

por Dhinakaran Sambandan, Dee N. Dao, Brian C. Weinrick, Catherine Vilchèze, Sudagar S. Gurcha, Anil Ojha, Laurent Kremer, Gurdyal S. Besra, Graham F. Hatfull, William R. Jacobs
Publicado 2013

Malaria infections do not compromise vaccine-induced immunity against tuberculosis in mice.

por Marcela Parra, Steven C Derrick, Amy Yang, Jinhua Tian, Kristopher Kolibab, Miranda Oakley, Liyanage P Perera, William R Jacobs, Sanjai Kumar, Sheldon L Morris
Publicado 2011

Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex

por Álvaro Chiner-Oms, Michael Berney, Christine Boinett, Fernando González-Candelas, Douglas B. Young, Sebastien Gagneux, William R. Jacobs, Julian Parkhill, Teresa Cortes, Iñaki Comas
Publicado 2019

Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection

por Erik J. Hasenoehrl, Dannah Rae Sajorda, Linda Berney-Meyer, Samantha Johnson, JoAnn M. Tufariello, Tobias Fuhrer, Gregory M. Cook, William R. Jacobs, Michael Berney
Publicado 2019

Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production.

por Dee N Dao, Kari Sweeney, Tsungda Hsu, Sudagar S Gurcha, Ivan P Nascimento, Ivan P Nascimento, Dan Roshevsky, Gurdyal S Besra, John Chan, Steven A Porcelli, William R Jacobs
Publicado 2008

Specialized Transduction Designed for Precise High-Throughput Unmarked Deletions in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>

por Paras Jain, Tsungda Hsu, Masayoshi Arai, Karolin Biermann, David S. Thaler, Andrew Nguyen, Pablo A. González, Joann M. Tufariello, Jordan Kriakov, Bing Chen, Michelle H. Larsen, William R. Jacobs
Publicado 2014

Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.

por Katherine C Yam, Igor D'Angelo, Rainer Kalscheuer, Haizhong Zhu, Jian-Xin Wang, Victor Snieckus, Lan H Ly, Paul J Converse, William R Jacobs, Natalie Strynadka, Lindsay D Eltis
Publicado 2009

Enhanced Specialized Transduction Using Recombineering in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>

por JoAnn M. Tufariello, Adel A. Malek, Catherine Vilchèze, Laura E. Cole, Hannah K. Ratner, Pablo A. González, Paras Jain, Graham F. Hatfull, Michelle H. Larsen, William R. Jacobs
Publicado 2014

Dual-Reporter Mycobacteriophages (Φ²DRMs) Reveal Preexisting <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Persistent Cells in H...

por Paras Jain, Brian C. Weinrick, Eric J. Kalivoda, Hui Yang, Vanisha Munsamy, Catherine Vilcheze, Torin R. Weisbrod, Michelle H. Larsen, Max R. O’Donnell, Alexander Pym, William R. Jacobs
Publicado 2016

Targeting <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antitubercu...

por Aaron Olsen, Yong Chen, Qingzhou Ji, Guofeng Zhu, Aruna Dharshan De Silva, Catherine Vilchèze, Torin Weisbrod, Weimin Li, Jiayong Xu, Michelle Larsen, Jinghang Zhang, Steven A. Porcelli, William R. Jacobs, John Chan
Publicado 2016

Genomics and Proteomics of Mycobacteriophage Patience, an Accidental Tourist in the <italic toggle="yes">Mycobacterium</italic> Neighborhood

por Welkin H. Pope, Deborah Jacobs-Sera, Daniel A. Russell, Daniel H. F. Rubin, Afsana Kajee, Zama N. P. Msibi, Michelle H. Larsen, William R. Jacobs, Jeffrey G. Lawrence, Roger W. Hendrix, Graham F. Hatfull
Publicado 2014

A Nonribosomal Peptide Synthase Gene Driving Virulence in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>

por Kiranmai Bhatt, Henrique Machado, Nuno S. Osório, Jeremy Sousa, Filipa Cardoso, Carlos Magalhães, Bing Chen, Mei Chen, John Kim, Albel Singh, Catarina M. Ferreira, António G. Castro, Egidio Torrado, William R. Jacobs, Apoorva Bhatt, Margarida Saraiva
Publicado 2018