The hydrolase LpqI primes mycobacterial peptidoglycan recycling

por Patrick J. Moynihan, Ian T. Cadby, Natacha Veerapen, Monika Jankute, Marialuisa Crosatti, Galina V. Mukamolova, Andrew L. Lovering, Gurdyal S. Besra
Publicado 2019

Lcp1 Is a Phosphotransferase Responsible for Ligating Arabinogalactan to Peptidoglycan in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>

por James Harrison, Georgina Lloyd, Maju Joe, Todd L. Lowary, Edward Reynolds, Hannah Walters-Morgan, Apoorva Bhatt, Andrew Lovering, Gurdyal S. Besra, Luke J. Alderwick
Publicado 2016

The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation

por Alice R. Moorey, Alejandro Cabanillas, Sarah M. Batt, Sonja Ghidelli-Disse, Beatriz Urones, Olalla Sanz, Joel Lelievre, Marcus Bantscheff, Liam R. Cox, Gurdyal S. Besra
Publicado 2021

Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>

por Dhinakaran Sambandan, Dee N. Dao, Brian C. Weinrick, Catherine Vilchèze, Sudagar S. Gurcha, Anil Ojha, Laurent Kremer, Gurdyal S. Besra, Graham F. Hatfull, William R. Jacobs
Publicado 2013

The role of hydrophobicity in tuberculosis evolution and pathogenicity

por Monika Jankute, Vijayashankar Nataraj, Oona Y. -C. Lee, Houdini H. T. Wu, Malin Ridell, Natalie J. Garton, Michael R. Barer, David E. Minnikin, Apoorva Bhatt, Gurdyal S. Besra
Publicado 2017

Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production.

por Dee N Dao, Kari Sweeney, Tsungda Hsu, Sudagar S Gurcha, Ivan P Nascimento, Ivan P Nascimento, Dan Roshevsky, Gurdyal S Besra, John Chan, Steven A Porcelli, William R Jacobs
Publicado 2008

Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets

por Valentin Trofimov, Sébastien Kicka, Sabrina Mucaria, Nabil Hanna, Fernando Ramon-Olayo, Laura Vela-Gonzalez Del Peral, Joël Lelièvre, Lluís Ballell, Leonardo Scapozza, Gurdyal S. Besra, Jonathan A. G. Cox, Thierry Soldati
Publicado 2018

Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum.

por Natalie J Garton, Simon J Waddell, Anna L Sherratt, Su-Min Lee, Rebecca J Smith, Claire Senner, Jason Hinds, Kumar Rajakumar, Richard A Adegbola, Gurdyal S Besra, Philip D Butcher, Michael R Barer
Publicado 2008

Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens

por Jérôme Le Nours, T. Praveena, Daniel G. Pellicci, Nicholas A. Gherardin, Fiona J. Ross, Ricky T. Lim, Gurdyal S. Besra, Santosh Keshipeddy, Stewart K. Richardson, Amy R. Howell, Stephanie Gras, Dale I. Godfrey, Jamie Rossjohn, Adam P. Uldrich
Publicado 2016

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A

por Lauren J. Howson, Giorgio Napolitani, Dawn Shepherd, Hemza Ghadbane, Prathiba Kurupati, Lorena Preciado-Llanes, Margarida Rei, Hazel C. Dobinson, Malick M. Gibani, Karen Wei Weng Teng, Evan W. Newell, Natacha Veerapen, Gurdyal S. Besra, Andrew J. Pollard, Vincenzo Cerundolo
Publicado 2018

Identification of KasA as the cellular target of an anti-tubercular scaffold

por Katherine A. Abrahams, Chun-wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S. Gurcha, Jonathan A. G. Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J. Loman, Patrick J. Moynihan, Joël Lelièvre, Carolyn Selenski, Matthew Axtman, Laurent Kremer, Marcus Bantscheff, Iñigo Angulo-Barturen, Mónica Cacho Izquierdo, Nicholas C. Cammack, Gerard Drewes, Lluis Ballell, David Barros, Gurdyal S. Besra, Robert H. Bates
Publicado 2016

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

por Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
Publicado 2017

Correction: Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

por Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
Publicado 2018