Identification of HSP90 inhibitors as a novel class of senolytics

The accumulation of senescent cells is thought to contribute to the age-associated decline in tissue function. Here, the authors identify HSP90 inhibitors as a new class of senolytic compounds in an in vitro screening and show that administration of a HSP90 inhibitor reduces age-related symptoms in...

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Autores principales:	Heike Fuhrmann-Stroissnigg, Yuan Yuan Ling, Jing Zhao, Sara J. McGowan, Yi Zhu, Robert W. Brooks, Diego Grassi, Siobhan Q. Gregg, Jennifer L. Stripay, Akaitz Dorronsoro, Lana Corbo, Priscilla Tang, Christina Bukata, Nadja Ring, Mauro Giacca, Xuesen Li, Tamara Tchkonia, James L. Kirkland, Laura J. Niedernhofer, Paul D. Robbins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6370fcbecaf7452cab92818e472747d7
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spelling	oai:doaj.org-article:6370fcbecaf7452cab92818e472747d72021-12-02T14:41:08ZIdentification of HSP90 inhibitors as a novel class of senolytics10.1038/s41467-017-00314-z2041-1723https://doaj.org/article/6370fcbecaf7452cab92818e472747d72017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00314-zhttps://doaj.org/toc/2041-1723The accumulation of senescent cells is thought to contribute to the age-associated decline in tissue function. Here, the authors identify HSP90 inhibitors as a new class of senolytic compounds in an in vitro screening and show that administration of a HSP90 inhibitor reduces age-related symptoms in progeroid mice.Heike Fuhrmann-StroissniggYuan Yuan LingJing ZhaoSara J. McGowanYi ZhuRobert W. BrooksDiego GrassiSiobhan Q. GreggJennifer L. StripayAkaitz DorronsoroLana CorboPriscilla TangChristina BukataNadja RingMauro GiaccaXuesen LiTamara TchkoniaJames L. KirklandLaura J. NiedernhoferPaul D. RobbinsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Heike Fuhrmann-Stroissnigg Yuan Yuan Ling Jing Zhao Sara J. McGowan Yi Zhu Robert W. Brooks Diego Grassi Siobhan Q. Gregg Jennifer L. Stripay Akaitz Dorronsoro Lana Corbo Priscilla Tang Christina Bukata Nadja Ring Mauro Giacca Xuesen Li Tamara Tchkonia James L. Kirkland Laura J. Niedernhofer Paul D. Robbins Identification of HSP90 inhibitors as a novel class of senolytics
description	The accumulation of senescent cells is thought to contribute to the age-associated decline in tissue function. Here, the authors identify HSP90 inhibitors as a new class of senolytic compounds in an in vitro screening and show that administration of a HSP90 inhibitor reduces age-related symptoms in progeroid mice.
format	article
author	Heike Fuhrmann-Stroissnigg Yuan Yuan Ling Jing Zhao Sara J. McGowan Yi Zhu Robert W. Brooks Diego Grassi Siobhan Q. Gregg Jennifer L. Stripay Akaitz Dorronsoro Lana Corbo Priscilla Tang Christina Bukata Nadja Ring Mauro Giacca Xuesen Li Tamara Tchkonia James L. Kirkland Laura J. Niedernhofer Paul D. Robbins
author_facet	Heike Fuhrmann-Stroissnigg Yuan Yuan Ling Jing Zhao Sara J. McGowan Yi Zhu Robert W. Brooks Diego Grassi Siobhan Q. Gregg Jennifer L. Stripay Akaitz Dorronsoro Lana Corbo Priscilla Tang Christina Bukata Nadja Ring Mauro Giacca Xuesen Li Tamara Tchkonia James L. Kirkland Laura J. Niedernhofer Paul D. Robbins
author_sort	Heike Fuhrmann-Stroissnigg
title	Identification of HSP90 inhibitors as a novel class of senolytics
title_short	Identification of HSP90 inhibitors as a novel class of senolytics
title_full	Identification of HSP90 inhibitors as a novel class of senolytics
title_fullStr	Identification of HSP90 inhibitors as a novel class of senolytics
title_full_unstemmed	Identification of HSP90 inhibitors as a novel class of senolytics
title_sort	identification of hsp90 inhibitors as a novel class of senolytics
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6370fcbecaf7452cab92818e472747d7
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Identification of HSP90 inhibitors as a novel class of senolytics

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