A non-canonical NRPS is involved in the synthesis of fungisporin and related hydrophobic cyclic tetrapeptides in Penicillium chrysogenum.

The filamentous fungus Penicillium chrysogenum harbors an astonishing variety of nonribosomal peptide synthetase genes, which encode proteins known to produce complex bioactive metabolites from simple building blocks. Here we report a novel non-canonical tetra-modular nonribosomal peptide synthetase...

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Auteurs principaux: Hazrat Ali, Marco I Ries, Peter P Lankhorst, Rob A M van der Hoeven, Olaf L Schouten, Marek Noga, Thomas Hankemeier, Noël N M E van Peij, Roel A L Bovenberg, Rob J Vreeken, Arnold J M Driessen
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2014
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R
Q
Accès en ligne:https://doaj.org/article/6380c87e856c4595a25ae2fd2cea9b99
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