CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer.

The induction of polyploidy is considered the reproductive end of cells, but there is evidence that polyploid giant cancer cells (PGCCs) contribute to cell repopulation during tumor relapse. However, the role of these cells in the development, progression and response to therapy in colon cancer rema...

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Autores principales: Laura M Lopez-Sánchez, Carla Jimenez, Araceli Valverde, Vanessa Hernandez, Jon Peñarando, Antonio Martinez, Chary Lopez-Pedrera, Juan R Muñoz-Castañeda, Juan R De la Haba-Rodríguez, Enrique Aranda, Antonio Rodriguez-Ariza
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/638a2701b50d4fbcb5190a00303e6296
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