Refining the Balance of Attenuation and Immunogenicity of Respiratory Syncytial Virus by Targeted Codon Deoptimization of Virulence Genes

Refining the Balance of Attenuation and Immunogenicity of Respiratory Syncytial Virus by Targeted Codon Deoptimization of Virulence Genes

ABSTRACT Respiratory syncytial virus (RSV) is the most important pathogen for lower respiratory tract illness in children for which there is no licensed vaccine. Live-attenuated RSV vaccines are the most clinically advanced in children, but achieving an optimal balance of attenuation and immunogenic...

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Bibliographic Details
Main Authors: Jia Meng, Sujin Lee, Anne L. Hotard, Martin L. Moore
Format: article
Language:EN
Published: American Society for Microbiology 2014
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/63a36e2a56d1416a98280f0b847e8ce1
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