Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson’s disease models

Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson’s disease models

Jin et al develop and characterise a blood-brain barrier and plasma membrane-permeable α-synuclein knockdown peptide, Tat-βsyn-degron. In two mouse models of Parkinson’s disease, they show that Tat-βsyn-degron decreases α-synuclein aggregates and microglial activation as well as reducing neuronal da...

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Bibliographic Details
Main Authors: Jack Wuyang Jin, Xuelai Fan, Esther del Cid-Pellitero, Xing-Xing Liu, Limin Zhou, Chunfang Dai, Ebrima Gibbs, Wenting He, Hongjie Li, Xiaobin Wu, Austin Hill, Blair R. Leavitt, Neil Cashman, Lidong Liu, Jie Lu, Thomas M. Durcan, Zhifang Dong, Edward A. Fon, Yu Tian Wang
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/63d676340fd343489fc159532b920ece
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https://doaj.org/article/63d676340fd343489fc159532b920ece

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