Alkylpurine glycosylase D employs DNA sculpting as a strategy to extrude and excise damaged bases.
Alkylpurine glycosylase D (AlkD) exhibits a unique base excision strategy. Instead of interacting directly with the lesion, the enzyme engages the non-lesion DNA strand. AlkD induces flipping of the alkylated and opposing base accompanied by DNA stack compression. Since this strategy leaves the alky...
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| Main Authors: | , |
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| Format: | article |
| Language: | EN |
| Published: |
Public Library of Science (PLoS)
2014
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| Subjects: | |
| Online Access: | https://doaj.org/article/63e64a743f234f9f95bdb27d42c54029 |
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