Flavin-dependent halogenases catalyze enantioselective olefin halocyclization

Catalytic enantioselective halocyclization of alkenes is an important bond forming tool and a key step in natural product biosynthesis, but so far no examples of the enzymatic counterpart of this reaction on simple achiral olefins have been reported. Here, the authors describe examples of engineered...

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Auteurs principaux: Dibyendu Mondal, Brian F. Fisher, Yuhua Jiang, Jared C. Lewis
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/63f27c4868c346a9a24685a83de202f3
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