Flavin-dependent halogenases catalyze enantioselective olefin halocyclization

Catalytic enantioselective halocyclization of alkenes is an important bond forming tool and a key step in natural product biosynthesis, but so far no examples of the enzymatic counterpart of this reaction on simple achiral olefins have been reported. Here, the authors describe examples of engineered...

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Autores principales:	Dibyendu Mondal, Brian F. Fisher, Yuhua Jiang, Jared C. Lewis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/63f27c4868c346a9a24685a83de202f3
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spelling	oai:doaj.org-article:63f27c4868c346a9a24685a83de202f32021-12-02T15:02:29ZFlavin-dependent halogenases catalyze enantioselective olefin halocyclization10.1038/s41467-021-23503-32041-1723https://doaj.org/article/63f27c4868c346a9a24685a83de202f32021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23503-3https://doaj.org/toc/2041-1723Catalytic enantioselective halocyclization of alkenes is an important bond forming tool and a key step in natural product biosynthesis, but so far no examples of the enzymatic counterpart of this reaction on simple achiral olefins have been reported. Here, the authors describe examples of engineered flavin-dependent halogenases that catalyze halolactonization of olefins with high enantioselectivity and near-native catalytic activity.Dibyendu MondalBrian F. FisherYuhua JiangJared C. LewisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dibyendu Mondal Brian F. Fisher Yuhua Jiang Jared C. Lewis Flavin-dependent halogenases catalyze enantioselective olefin halocyclization
description	Catalytic enantioselective halocyclization of alkenes is an important bond forming tool and a key step in natural product biosynthesis, but so far no examples of the enzymatic counterpart of this reaction on simple achiral olefins have been reported. Here, the authors describe examples of engineered flavin-dependent halogenases that catalyze halolactonization of olefins with high enantioselectivity and near-native catalytic activity.
format	article
author	Dibyendu Mondal Brian F. Fisher Yuhua Jiang Jared C. Lewis
author_facet	Dibyendu Mondal Brian F. Fisher Yuhua Jiang Jared C. Lewis
author_sort	Dibyendu Mondal
title	Flavin-dependent halogenases catalyze enantioselective olefin halocyclization
title_short	Flavin-dependent halogenases catalyze enantioselective olefin halocyclization
title_full	Flavin-dependent halogenases catalyze enantioselective olefin halocyclization
title_fullStr	Flavin-dependent halogenases catalyze enantioselective olefin halocyclization
title_full_unstemmed	Flavin-dependent halogenases catalyze enantioselective olefin halocyclization
title_sort	flavin-dependent halogenases catalyze enantioselective olefin halocyclization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/63f27c4868c346a9a24685a83de202f3
work_keys_str_mv	AT dibyendumondal flavindependenthalogenasescatalyzeenantioselectiveolefinhalocyclization AT brianffisher flavindependenthalogenasescatalyzeenantioselectiveolefinhalocyclization AT yuhuajiang flavindependenthalogenasescatalyzeenantioselectiveolefinhalocyclization AT jaredclewis flavindependenthalogenasescatalyzeenantioselectiveolefinhalocyclization
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Flavin-dependent halogenases catalyze enantioselective olefin halocyclization

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