Flavin-dependent halogenases catalyze enantioselective olefin halocyclization

Catalytic enantioselective halocyclization of alkenes is an important bond forming tool and a key step in natural product biosynthesis, but so far no examples of the enzymatic counterpart of this reaction on simple achiral olefins have been reported. Here, the authors describe examples of engineered...

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Bibliographic Details
Main Authors: Dibyendu Mondal, Brian F. Fisher, Yuhua Jiang, Jared C. Lewis
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/63f27c4868c346a9a24685a83de202f3
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