CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics.

CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics.

Here, we describe the generation of a novel type of HIV entry inhibitor using the recently developed Designed Ankyrin Repeat Protein (DARPin) technology. DARPin proteins specific for human CD4 were selected from a DARPin DNA library using ribosome display. Selected pool members interacted specifical...

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Bibliographic Details
Main Authors: Andreas Schweizer, Peter Rusert, Livia Berlinger, Claudia R Ruprecht, Axel Mann, Stéphanie Corthésy, Stuart G Turville, Meropi Aravantinou, Marek Fischer, Melissa Robbiani, Patrick Amstutz, Alexandra Trkola
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2008
Subjects:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/63f2e46f9bed439bb295b004f6d2249c
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https://doaj.org/article/63f2e46f9bed439bb295b004f6d2249c

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