AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice

Ericsson et al. show in aged mice that the panAMPK activator O304 prevents and reverts age-associated hyperinsulinemia and insulin resistance, as well as improving cardiac function and exercise capacity. O304 thus functions as an exercise mimetic and could therefore have a similar therapeutic potent...

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Autores principales: Madelene Ericsson, Pär Steneberg, Rakel Nyrén, Helena Edlund
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/64086dace18d49488ccbf433e4550abd
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