AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice

Ericsson et al. show in aged mice that the panAMPK activator O304 prevents and reverts age-associated hyperinsulinemia and insulin resistance, as well as improving cardiac function and exercise capacity. O304 thus functions as an exercise mimetic and could therefore have a similar therapeutic potent...

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Autores principales:	Madelene Ericsson, Pär Steneberg, Rakel Nyrén, Helena Edlund
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/64086dace18d49488ccbf433e4550abd
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spelling	oai:doaj.org-article:64086dace18d49488ccbf433e4550abd2021-11-21T12:08:24ZAMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice10.1038/s42003-021-02837-02399-3642https://doaj.org/article/64086dace18d49488ccbf433e4550abd2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02837-0https://doaj.org/toc/2399-3642Ericsson et al. show in aged mice that the panAMPK activator O304 prevents and reverts age-associated hyperinsulinemia and insulin resistance, as well as improving cardiac function and exercise capacity. O304 thus functions as an exercise mimetic and could therefore have a similar therapeutic potential in aged humans and improve quality of life.Madelene EricssonPär StenebergRakel NyrénHelena EdlundNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Madelene Ericsson Pär Steneberg Rakel Nyrén Helena Edlund AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice
description	Ericsson et al. show in aged mice that the panAMPK activator O304 prevents and reverts age-associated hyperinsulinemia and insulin resistance, as well as improving cardiac function and exercise capacity. O304 thus functions as an exercise mimetic and could therefore have a similar therapeutic potential in aged humans and improve quality of life.
format	article
author	Madelene Ericsson Pär Steneberg Rakel Nyrén Helena Edlund
author_facet	Madelene Ericsson Pär Steneberg Rakel Nyrén Helena Edlund
author_sort	Madelene Ericsson
title	AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice
title_short	AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice
title_full	AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice
title_fullStr	AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice
title_full_unstemmed	AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice
title_sort	ampk activator o304 improves metabolic and cardiac function, and exercise capacity in aged mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/64086dace18d49488ccbf433e4550abd
work_keys_str_mv	AT madeleneericsson ampkactivatoro304improvesmetabolicandcardiacfunctionandexercisecapacityinagedmice AT parsteneberg ampkactivatoro304improvesmetabolicandcardiacfunctionandexercisecapacityinagedmice AT rakelnyren ampkactivatoro304improvesmetabolicandcardiacfunctionandexercisecapacityinagedmice AT helenaedlund ampkactivatoro304improvesmetabolicandcardiacfunctionandexercisecapacityinagedmice
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AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice

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