PrimeDesign software for rapid and simplified design of prime editing guide RNAs

Prime editing guide RNA design is more complex than for standard CRISPR-based nucleases or base editors. Here the authors present PrimeDesign and PrimeVar for the rapid and simplified design of pegRNA and ngRNA combinations.

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Autores principales:	Jonathan Y. Hsu, Julian Grünewald, Regan Szalay, Justine Shih, Andrew V. Anzalone, Kin Chung Lam, Max W. Shen, Karl Petri, David R. Liu, J. Keith Joung, Luca Pinello
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/641f29fd5ac64f28bbea06a81c5212bd
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spelling	oai:doaj.org-article:641f29fd5ac64f28bbea06a81c5212bd2021-12-02T12:11:27ZPrimeDesign software for rapid and simplified design of prime editing guide RNAs10.1038/s41467-021-21337-72041-1723https://doaj.org/article/641f29fd5ac64f28bbea06a81c5212bd2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21337-7https://doaj.org/toc/2041-1723Prime editing guide RNA design is more complex than for standard CRISPR-based nucleases or base editors. Here the authors present PrimeDesign and PrimeVar for the rapid and simplified design of pegRNA and ngRNA combinations.Jonathan Y. HsuJulian GrünewaldRegan SzalayJustine ShihAndrew V. AnzaloneKin Chung LamMax W. ShenKarl PetriDavid R. LiuJ. Keith JoungLuca PinelloNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonathan Y. Hsu Julian Grünewald Regan Szalay Justine Shih Andrew V. Anzalone Kin Chung Lam Max W. Shen Karl Petri David R. Liu J. Keith Joung Luca Pinello PrimeDesign software for rapid and simplified design of prime editing guide RNAs
description	Prime editing guide RNA design is more complex than for standard CRISPR-based nucleases or base editors. Here the authors present PrimeDesign and PrimeVar for the rapid and simplified design of pegRNA and ngRNA combinations.
format	article
author	Jonathan Y. Hsu Julian Grünewald Regan Szalay Justine Shih Andrew V. Anzalone Kin Chung Lam Max W. Shen Karl Petri David R. Liu J. Keith Joung Luca Pinello
author_facet	Jonathan Y. Hsu Julian Grünewald Regan Szalay Justine Shih Andrew V. Anzalone Kin Chung Lam Max W. Shen Karl Petri David R. Liu J. Keith Joung Luca Pinello
author_sort	Jonathan Y. Hsu
title	PrimeDesign software for rapid and simplified design of prime editing guide RNAs
title_short	PrimeDesign software for rapid and simplified design of prime editing guide RNAs
title_full	PrimeDesign software for rapid and simplified design of prime editing guide RNAs
title_fullStr	PrimeDesign software for rapid and simplified design of prime editing guide RNAs
title_full_unstemmed	PrimeDesign software for rapid and simplified design of prime editing guide RNAs
title_sort	primedesign software for rapid and simplified design of prime editing guide rnas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/641f29fd5ac64f28bbea06a81c5212bd
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PrimeDesign software for rapid and simplified design of prime editing guide RNAs

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