Machine learning based CRISPR gRNA design for therapeutic exon skipping.

por Wilson Louie, Max W Shen, Zakir Tahiry, Sophia Zhang, Daniel Worstell, Christopher A Cassa, Richard I Sherwood, David K Gifford
Publicado 2021

Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency

por Heysol C. Bermudez-Cabrera, Sannie Culbertson, Sammy Barkal, Benjamin Holmes, Max W. Shen, Sophia Zhang, David K. Gifford, Richard I. Sherwood
Publicado 2021

Detection of gene cis-regulatory element perturbations in single-cell transcriptomes.

por Grace Hui Ting Yeo, Oscar Juez, Qing Chen, Budhaditya Banerjee, Lendy Chu, Max W Shen, May Sabry, Ive Logister, Richard I Sherwood, David K Gifford
Publicado 2021

PrimeDesign software for rapid and simplified design of prime editing guide RNAs

por Jonathan Y. Hsu, Julian Grünewald, Regan Szalay, Justine Shih, Andrew V. Anzalone, Kin Chung Lam, Max W. Shen, Karl Petri, David R. Liu, J. Keith Joung, Luca Pinello
Publicado 2021