Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death.

Human APOBEC3 enzymes deaminate single stranded DNA. At least five can deaminate mitochondrial DNA in the cytoplasm, while three can deaminate viral DNA in the nucleus. However, only one, APOBEC3A, can hypermutate genomic DNA. We analysed the distribution and function of the two APOBEC3A isoforms p1...

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Auteurs principaux: Bianka Mussil, Rodolphe Suspène, Marie-Ming Aynaud, Anne Gauvrit, Jean-Pierre Vartanian, Simon Wain-Hobson
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2013
Sujets:
R
Q
Accès en ligne:https://doaj.org/article/644e6451a7ab47d391e496f32021d022
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