GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease

Cholinergic interneurons of the striatum are involved reward-related behaviors and have been implicated in Parkinson’s disease. Here the authors report that half of cholinergic neurons co-release acetylcholine and GABA, and study the role of these neurons in a model of Parkinson’s Disease.

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Autores principales:	N. Lozovaya, S. Eftekhari, R. Cloarec, L. A. Gouty-Colomer, A. Dufour, B. Riffault, M. Billon-Grand, A. Pons-Bennaceur, N. Oumar, N. Burnashev, Y. Ben-Ari, C. Hammond
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6462473cc62646758946f586af2ca644
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spelling	oai:doaj.org-article:6462473cc62646758946f586af2ca6442021-12-02T14:38:51ZGABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease10.1038/s41467-018-03802-y2041-1723https://doaj.org/article/6462473cc62646758946f586af2ca6442018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03802-yhttps://doaj.org/toc/2041-1723Cholinergic interneurons of the striatum are involved reward-related behaviors and have been implicated in Parkinson’s disease. Here the authors report that half of cholinergic neurons co-release acetylcholine and GABA, and study the role of these neurons in a model of Parkinson’s Disease.N. LozovayaS. EftekhariR. CloarecL. A. Gouty-ColomerA. DufourB. RiffaultM. Billon-GrandA. Pons-BennaceurN. OumarN. BurnashevY. Ben-AriC. HammondNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q N. Lozovaya S. Eftekhari R. Cloarec L. A. Gouty-Colomer A. Dufour B. Riffault M. Billon-Grand A. Pons-Bennaceur N. Oumar N. Burnashev Y. Ben-Ari C. Hammond GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease
description	Cholinergic interneurons of the striatum are involved reward-related behaviors and have been implicated in Parkinson’s disease. Here the authors report that half of cholinergic neurons co-release acetylcholine and GABA, and study the role of these neurons in a model of Parkinson’s Disease.
format	article
author	N. Lozovaya S. Eftekhari R. Cloarec L. A. Gouty-Colomer A. Dufour B. Riffault M. Billon-Grand A. Pons-Bennaceur N. Oumar N. Burnashev Y. Ben-Ari C. Hammond
author_facet	N. Lozovaya S. Eftekhari R. Cloarec L. A. Gouty-Colomer A. Dufour B. Riffault M. Billon-Grand A. Pons-Bennaceur N. Oumar N. Burnashev Y. Ben-Ari C. Hammond
author_sort	N. Lozovaya
title	GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease
title_short	GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease
title_full	GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease
title_fullStr	GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease
title_full_unstemmed	GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease
title_sort	gabaergic inhibition in dual-transmission cholinergic and gabaergic striatal interneurons is abolished in parkinson disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6462473cc62646758946f586af2ca644
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GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease

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