Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden

Germline variants that affect the expression or function of protein-coding regions of cancer genes are associated with cancer susceptibility. Here, the authors show that a larger number of germline variants are present in early-onset cancers, while acquired somatic mutations are prevalent in cancers...

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Autores principales:	Tao Qing, Hussein Mohsen, Michal Marczyk, Yixuan Ye, Tess O’Meara, Hongyu Zhao, Jeffrey P. Townsend, Mark Gerstein, Christos Hatzis, Yuval Kluger, Lajos Pusztai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6465db3a292f40d4a8d14f8e7096e431
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spelling	oai:doaj.org-article:6465db3a292f40d4a8d14f8e7096e4312021-12-02T17:15:59ZGermline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden10.1038/s41467-020-16293-72041-1723https://doaj.org/article/6465db3a292f40d4a8d14f8e7096e4312020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16293-7https://doaj.org/toc/2041-1723Germline variants that affect the expression or function of protein-coding regions of cancer genes are associated with cancer susceptibility. Here, the authors show that a larger number of germline variants are present in early-onset cancers, while acquired somatic mutations are prevalent in cancers that develop at older age.Tao QingHussein MohsenMichal MarczykYixuan YeTess O’MearaHongyu ZhaoJeffrey P. TownsendMark GersteinChristos HatzisYuval KlugerLajos PusztaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tao Qing Hussein Mohsen Michal Marczyk Yixuan Ye Tess O’Meara Hongyu Zhao Jeffrey P. Townsend Mark Gerstein Christos Hatzis Yuval Kluger Lajos Pusztai Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
description	Germline variants that affect the expression or function of protein-coding regions of cancer genes are associated with cancer susceptibility. Here, the authors show that a larger number of germline variants are present in early-onset cancers, while acquired somatic mutations are prevalent in cancers that develop at older age.
format	article
author	Tao Qing Hussein Mohsen Michal Marczyk Yixuan Ye Tess O’Meara Hongyu Zhao Jeffrey P. Townsend Mark Gerstein Christos Hatzis Yuval Kluger Lajos Pusztai
author_facet	Tao Qing Hussein Mohsen Michal Marczyk Yixuan Ye Tess O’Meara Hongyu Zhao Jeffrey P. Townsend Mark Gerstein Christos Hatzis Yuval Kluger Lajos Pusztai
author_sort	Tao Qing
title	Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
title_short	Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
title_full	Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
title_fullStr	Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
title_full_unstemmed	Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
title_sort	germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6465db3a292f40d4a8d14f8e7096e431
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Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden

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