Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden

Germline variants that affect the expression or function of protein-coding regions of cancer genes are associated with cancer susceptibility. Here, the authors show that a larger number of germline variants are present in early-onset cancers, while acquired somatic mutations are prevalent in cancers...

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Bibliographic Details
Main Authors: Tao Qing, Hussein Mohsen, Michal Marczyk, Yixuan Ye, Tess O’Meara, Hongyu Zhao, Jeffrey P. Townsend, Mark Gerstein, Christos Hatzis, Yuval Kluger, Lajos Pusztai
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/6465db3a292f40d4a8d14f8e7096e431
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