Insights into Intra-Tumoral Heterogeneity: Transcriptional Profiling of Chemoresistant MPM Cell Subpopulations Reveals Involvement of NFkB and DNA Repair Pathways and Contributes a Prognostic Signature

Insights into Intra-Tumoral Heterogeneity: Transcriptional Profiling of Chemoresistant MPM Cell Subpopulations Reveals Involvement of NFkB and DNA Repair Pathways and Contributes a Prognostic Signature

Chemoresistance is a hallmark of malignant pleural mesothelioma (MPM) management and the expression of ALDH1A3 is responsible for the survival and activity of MPM chemoresistant cell subpopulations (ALDH<sup>bright</sup> cells). We enriched mesothelioma ALDH<sup>bright</sup>...

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Autores principales: Mario Cioce, Andrea Sacconi, Harvey I. Pass, Claudia Canino, Sabrina Strano, Giovanni Blandino, Vito Michele Fazio
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
chemoresistance
ALDH
gene expression
NFkB
DNA repair
butein
Biology (General)
QH301-705.5
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/64907bf460be4b21a85887a4a7f86875
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https://doaj.org/article/64907bf460be4b21a85887a4a7f86875

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