Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

How DNA polymerases discriminate against oxidized and undamaged nucleotides during DNA repair is not fully understood. Here, the authors reveal high-resolution timelapse X-ray crystallography snapshots of DSB repair polymerase μ undergoing DNA synthesis providing mechanistic insights into the proces...

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Autores principales: Joonas A. Jamsen, Akira Sassa, David D. Shock, William A. Beard, Samuel H. Wilson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/64968d1c0b29445aac6abe67bd0ccdd1
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