Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

How DNA polymerases discriminate against oxidized and undamaged nucleotides during DNA repair is not fully understood. Here, the authors reveal high-resolution timelapse X-ray crystallography snapshots of DSB repair polymerase μ undergoing DNA synthesis providing mechanistic insights into the proces...

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Auteurs principaux:	Joonas A. Jamsen, Akira Sassa, David D. Shock, William A. Beard, Samuel H. Wilson
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/64968d1c0b29445aac6abe67bd0ccdd1
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id	oai:doaj.org-article:64968d1c0b29445aac6abe67bd0ccdd1
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spelling	oai:doaj.org-article:64968d1c0b29445aac6abe67bd0ccdd12021-12-02T14:37:27ZWatching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide10.1038/s41467-021-21354-62041-1723https://doaj.org/article/64968d1c0b29445aac6abe67bd0ccdd12021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21354-6https://doaj.org/toc/2041-1723How DNA polymerases discriminate against oxidized and undamaged nucleotides during DNA repair is not fully understood. Here, the authors reveal high-resolution timelapse X-ray crystallography snapshots of DSB repair polymerase μ undergoing DNA synthesis providing mechanistic insights into the process.Joonas A. JamsenAkira SassaDavid D. ShockWilliam A. BeardSamuel H. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joonas A. Jamsen Akira Sassa David D. Shock William A. Beard Samuel H. Wilson Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
description	How DNA polymerases discriminate against oxidized and undamaged nucleotides during DNA repair is not fully understood. Here, the authors reveal high-resolution timelapse X-ray crystallography snapshots of DSB repair polymerase μ undergoing DNA synthesis providing mechanistic insights into the process.
format	article
author	Joonas A. Jamsen Akira Sassa David D. Shock William A. Beard Samuel H. Wilson
author_facet	Joonas A. Jamsen Akira Sassa David D. Shock William A. Beard Samuel H. Wilson
author_sort	Joonas A. Jamsen
title	Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
title_short	Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
title_full	Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
title_fullStr	Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
title_full_unstemmed	Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
title_sort	watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/64968d1c0b29445aac6abe67bd0ccdd1
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Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

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