Rational modification of estrogen receptor by combination of computational and experimental analysis.

In this manuscript, we modulate the binding properties of estrogen receptor protein by rationally modifying the amino acid composition of its ligand binding domain. By combining sequence alignment and structural analysis of known estrogen receptor-ligand complexes with computational analysis, we wer...

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Autores principales: Valentina Elisabetta Viviana Ferrero, Mattia Pedotti, Alessandro Chiadò, Luca Simonelli, Luigi Calzolai, Luca Varani, Teresa Lettieri
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/64b1833085ed4db2a395c5ebcacef1c0
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