The synaptic receptor Lrp4 promotes peripheral nerve regeneration

Axons of the peripheral nervous system regenerate along Schwann cells following injury. Here, the authors show that regenerating axons follow pioneer axons and this process is mediated by lipoprotein receptor-related protein 4 (Lrp4), a protein otherwise known for its role in synapse formation.

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Detalles Bibliográficos
Autores principales: Katherine D. Gribble, Lauren J. Walker, Louis Saint-Amant, John Y. Kuwada, Michael Granato
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
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Acceso en línea:https://doaj.org/article/64b3962177964d1280be358fae515cc7
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Descripción
Sumario:Axons of the peripheral nervous system regenerate along Schwann cells following injury. Here, the authors show that regenerating axons follow pioneer axons and this process is mediated by lipoprotein receptor-related protein 4 (Lrp4), a protein otherwise known for its role in synapse formation.