The synaptic receptor Lrp4 promotes peripheral nerve regeneration

Axons of the peripheral nervous system regenerate along Schwann cells following injury. Here, the authors show that regenerating axons follow pioneer axons and this process is mediated by lipoprotein receptor-related protein 4 (Lrp4), a protein otherwise known for its role in synapse formation.

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Autores principales: Katherine D. Gribble, Lauren J. Walker, Louis Saint-Amant, John Y. Kuwada, Michael Granato
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/64b3962177964d1280be358fae515cc7
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spelling oai:doaj.org-article:64b3962177964d1280be358fae515cc72021-12-02T13:27:31ZThe synaptic receptor Lrp4 promotes peripheral nerve regeneration10.1038/s41467-018-04806-42041-1723https://doaj.org/article/64b3962177964d1280be358fae515cc72018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04806-4https://doaj.org/toc/2041-1723Axons of the peripheral nervous system regenerate along Schwann cells following injury. Here, the authors show that regenerating axons follow pioneer axons and this process is mediated by lipoprotein receptor-related protein 4 (Lrp4), a protein otherwise known for its role in synapse formation.Katherine D. GribbleLauren J. WalkerLouis Saint-AmantJohn Y. KuwadaMichael GranatoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Katherine D. Gribble
Lauren J. Walker
Louis Saint-Amant
John Y. Kuwada
Michael Granato
The synaptic receptor Lrp4 promotes peripheral nerve regeneration
description Axons of the peripheral nervous system regenerate along Schwann cells following injury. Here, the authors show that regenerating axons follow pioneer axons and this process is mediated by lipoprotein receptor-related protein 4 (Lrp4), a protein otherwise known for its role in synapse formation.
format article
author Katherine D. Gribble
Lauren J. Walker
Louis Saint-Amant
John Y. Kuwada
Michael Granato
author_facet Katherine D. Gribble
Lauren J. Walker
Louis Saint-Amant
John Y. Kuwada
Michael Granato
author_sort Katherine D. Gribble
title The synaptic receptor Lrp4 promotes peripheral nerve regeneration
title_short The synaptic receptor Lrp4 promotes peripheral nerve regeneration
title_full The synaptic receptor Lrp4 promotes peripheral nerve regeneration
title_fullStr The synaptic receptor Lrp4 promotes peripheral nerve regeneration
title_full_unstemmed The synaptic receptor Lrp4 promotes peripheral nerve regeneration
title_sort synaptic receptor lrp4 promotes peripheral nerve regeneration
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/64b3962177964d1280be358fae515cc7
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