The synaptic receptor Lrp4 promotes peripheral nerve regeneration
Axons of the peripheral nervous system regenerate along Schwann cells following injury. Here, the authors show that regenerating axons follow pioneer axons and this process is mediated by lipoprotein receptor-related protein 4 (Lrp4), a protein otherwise known for its role in synapse formation.
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Nature Portfolio
2018
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oai:doaj.org-article:64b3962177964d1280be358fae515cc72021-12-02T13:27:31ZThe synaptic receptor Lrp4 promotes peripheral nerve regeneration10.1038/s41467-018-04806-42041-1723https://doaj.org/article/64b3962177964d1280be358fae515cc72018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04806-4https://doaj.org/toc/2041-1723Axons of the peripheral nervous system regenerate along Schwann cells following injury. Here, the authors show that regenerating axons follow pioneer axons and this process is mediated by lipoprotein receptor-related protein 4 (Lrp4), a protein otherwise known for its role in synapse formation.Katherine D. GribbleLauren J. WalkerLouis Saint-AmantJohn Y. KuwadaMichael GranatoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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Science Q |
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Science Q Katherine D. Gribble Lauren J. Walker Louis Saint-Amant John Y. Kuwada Michael Granato The synaptic receptor Lrp4 promotes peripheral nerve regeneration |
description |
Axons of the peripheral nervous system regenerate along Schwann cells following injury. Here, the authors show that regenerating axons follow pioneer axons and this process is mediated by lipoprotein receptor-related protein 4 (Lrp4), a protein otherwise known for its role in synapse formation. |
format |
article |
author |
Katherine D. Gribble Lauren J. Walker Louis Saint-Amant John Y. Kuwada Michael Granato |
author_facet |
Katherine D. Gribble Lauren J. Walker Louis Saint-Amant John Y. Kuwada Michael Granato |
author_sort |
Katherine D. Gribble |
title |
The synaptic receptor Lrp4 promotes peripheral nerve regeneration |
title_short |
The synaptic receptor Lrp4 promotes peripheral nerve regeneration |
title_full |
The synaptic receptor Lrp4 promotes peripheral nerve regeneration |
title_fullStr |
The synaptic receptor Lrp4 promotes peripheral nerve regeneration |
title_full_unstemmed |
The synaptic receptor Lrp4 promotes peripheral nerve regeneration |
title_sort |
synaptic receptor lrp4 promotes peripheral nerve regeneration |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/64b3962177964d1280be358fae515cc7 |
work_keys_str_mv |
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