Investigating the causal role of MRE11A p.E506* in breast and ovarian cancer

Investigating the causal role of MRE11A p.E506* in breast and ovarian cancer

Abstract The nuclease MRE11A is often included in genetic test panels for hereditary breast and ovarian cancer (HBOC) due to its BRCA1-related molecular function in the DNA repair pathway. However, whether MRE11A is a true predisposition gene for HBOC is still questionable. We determined to investig...

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Main Authors: Islam E. Elkholi, Massimo Di Iorio, Somayyeh Fahiminiya, Suzanna L. Arcand, HyeRim Han, Clara Nogué, Supriya Behl, Nancy Hamel, Sylvie Giroux, Manon de Ladurantaye, Olga Aleynikova, Walter H. Gotlieb, Jean-François Côté, François Rousseau, Patricia N. Tonin, Diane Provencher, Anne-Marie MesMasson, Mohammad R. Akbari, Barbara Rivera, William D. Foulkes
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/64c0a0aadac845d4b26d482428971ff5
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https://doaj.org/article/64c0a0aadac845d4b26d482428971ff5

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