Crystal structure of mammalian acid sphingomyelinase

Mutations in acid sphingomyelinase result in toxic accumulation of sphingomyelin and cause Niemann-Pick disease. Here, the authors report structures of mammalian acid sphingomyelinase, which reveal details of the molecular mechanism of acid sphingomyelinase function and regulation.

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Auteurs principaux: Alexei Gorelik, Katalin Illes, Leonhard X. Heinz, Giulio Superti-Furga, Bhushan Nagar
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/64dbae6e66f941cbb1af708261839ee8
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