Crystal structure of mammalian acid sphingomyelinase

Mutations in acid sphingomyelinase result in toxic accumulation of sphingomyelin and cause Niemann-Pick disease. Here, the authors report structures of mammalian acid sphingomyelinase, which reveal details of the molecular mechanism of acid sphingomyelinase function and regulation.

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Autores principales:	Alexei Gorelik, Katalin Illes, Leonhard X. Heinz, Giulio Superti-Furga, Bhushan Nagar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/64dbae6e66f941cbb1af708261839ee8
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spelling	oai:doaj.org-article:64dbae6e66f941cbb1af708261839ee82021-12-02T17:32:08ZCrystal structure of mammalian acid sphingomyelinase10.1038/ncomms121962041-1723https://doaj.org/article/64dbae6e66f941cbb1af708261839ee82016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12196https://doaj.org/toc/2041-1723Mutations in acid sphingomyelinase result in toxic accumulation of sphingomyelin and cause Niemann-Pick disease. Here, the authors report structures of mammalian acid sphingomyelinase, which reveal details of the molecular mechanism of acid sphingomyelinase function and regulation.Alexei GorelikKatalin IllesLeonhard X. HeinzGiulio Superti-FurgaBhushan NagarNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexei Gorelik Katalin Illes Leonhard X. Heinz Giulio Superti-Furga Bhushan Nagar Crystal structure of mammalian acid sphingomyelinase
description	Mutations in acid sphingomyelinase result in toxic accumulation of sphingomyelin and cause Niemann-Pick disease. Here, the authors report structures of mammalian acid sphingomyelinase, which reveal details of the molecular mechanism of acid sphingomyelinase function and regulation.
format	article
author	Alexei Gorelik Katalin Illes Leonhard X. Heinz Giulio Superti-Furga Bhushan Nagar
author_facet	Alexei Gorelik Katalin Illes Leonhard X. Heinz Giulio Superti-Furga Bhushan Nagar
author_sort	Alexei Gorelik
title	Crystal structure of mammalian acid sphingomyelinase
title_short	Crystal structure of mammalian acid sphingomyelinase
title_full	Crystal structure of mammalian acid sphingomyelinase
title_fullStr	Crystal structure of mammalian acid sphingomyelinase
title_full_unstemmed	Crystal structure of mammalian acid sphingomyelinase
title_sort	crystal structure of mammalian acid sphingomyelinase
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/64dbae6e66f941cbb1af708261839ee8
work_keys_str_mv	AT alexeigorelik crystalstructureofmammalianacidsphingomyelinase AT katalinilles crystalstructureofmammalianacidsphingomyelinase AT leonhardxheinz crystalstructureofmammalianacidsphingomyelinase AT giuliosupertifurga crystalstructureofmammalianacidsphingomyelinase AT bhushannagar crystalstructureofmammalianacidsphingomyelinase
_version_	1718380373104132096

Crystal structure of mammalian acid sphingomyelinase

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